Am J Hum Genet. 2016 Aug 4;99(2):352-65. doi: 10.1016/j.ajhg.2016.06.018. Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus. Dai JY, Tapsoba Jde D, Buas MF; BEACON Consortium, Risch HA, Vaughan TL Abstract Few gene-environment interactions (G × E) have been discovered in cancer epidemiology thus far, in part due to the large number of possible … Continue reading →
Lancet Oncol. 2016 Oct;17(10):1363-1373. doi: 10.1016/S1470-2045(16)30240-6. Epub 2016 Aug 12. Genome-wide association studies in oesophageal adenocarcinoma and Barrett’s oesophagus: a large-scale meta-analysis. Gharahkhani P, Fitzgerald RC, Vaughan TL, et al. Abstract BACKGROUND: Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett’s oesophagus is the premalignant precursor of oesophageal adenocarcinoma. However, only a few patients with Barrett’s … Continue reading →
The publications page has been update with 10 (!) new BEACON publications. Two others have been submitted. We are no longer using BaseCamp for managing BEACON resources due to cost contraints. All study questionnaires and other documents that were on BaseCamp are being kept on an encrypted website and available to members by request. … Continue reading →
The date and location of the next workshop is yet to be determined.
Gut. 2016 Aug 2. pii: gutjnl-2016-311622. doi: 10.1136/gutjnl-2016-311622. [Epub ahead of print] Germline variation in inflammation-related pathways and risk of Barrett’s oesophagus and oesophageal adenocarcinoma. Buas MF, He Q, Johnson LG, Onstad L, Levine DM, Thrift AP, Gharahkhani P, Palles C, Lagergren J, Fitzgerald RC, Ye W, Caldas C, Bird NC, Shaheen NJ, Bernstein L, Gammon MD, Wu AH, Hardie … Continue reading →
Cancer Med. 2016 Jul 6. doi: 10.1002/cam4.810. [Epub ahead of print] Leukocyte telomere length in relation to the risk of Barrett’s esophagus and esophageal adenocarcinoma. Wennerström EC, Risques RA, Prunkard D, Giffen C, Corley DA, Murray LJ, Whiteman DC, Wu AH, Bernstein L, Ye W, Chow WH, Vaughan TL, Liao LM. Abstract Chronic inflammation and oxidative damage caused by obesity, … Continue reading →
Clin Gastroenterol Hepatol. 2016 Jun 2. pii: S1542-3565(16)30267-1. doi: 10.1016/j.cgh.2016.05.032. [Epub ahead of print] Inverse Association Between Gluteofemoral Obesity and Risk of Barrett’s Esophagus in a Pooled Analysis. Kendall BJ, Rubenstein JH, Cook MB, Vaughan TL, Anderson LA, Murray LJ, Shaheen NJ, Corley DA, Chandar AK, Li L, Greer KB, Chak A, El-Serag HB, Whiteman DC, Thrift AP Abstract BACKGROUND & … Continue reading →