Kit Curtius and colleagues from the U.S. and India demonstrate how mathematical modeling of cancer evolution can be used to optimize age at initial screening for Barrett's and esophageal adenocarcinoma. Their research
EAC became the most common form of esophageal cancer in Switzerland around 2010. From the authors' conclusions: A significant increase in the incidence of adenocarcinoma of the oesophagus was observed in Switzerland during
Over 350,000 records were analyzed to identify genetic markers (SNPs) and genes related to the prevalence of GERD (gastroesophageal reflux.) 25 new loci were identified, most of which also associated with increased
Strengths of this risk prediction model for Barrett's includes the relatively large number of cases and an external validation dataset. A limitation is that only those with symtomatic GERD (reflux) were included, so
This review paper summarizes some of the current issues in surveillance and treatment after endoscopic eradication therapy (e.g., RFA) for Barrett's dysplasia. Am J Gastroenterol. 2020 Jan 3. doi: 10.14309/ajg.
Investigators in the CISNET Esophagus consortium employed comparative modeling to develop recommendations on clinical management (surveillance frequency and endoscopic eradication therapy) of persons with low grade or non-dysplastic Barrett's esophagus. Clin Gastroenterol Hepatol.