July 15, 2019

Trends in Esophageal Cancer Incidence

Trends in Esophageal Cancer Incidence

Investigators from Queen Mary University of London examine past trends in esophageal cancer incidence and project a leveling off in rates of esophageal adenocarcinoma over the next two decades.

Br J Cancer. 2018 May;118(10):1391-1398. doi: 10.1038/s41416-018-0047-4. Epub  2018 Mar 22.

Offman J1, Pesola F2, Sasieni P2,3.



The aim of this study was to assess the incidence and trends of oesophageal adenocarcinomas (OACs) and squamous cell carcinomas (OSCCs) in England from 1971 to 2037.


Data  on 220,026 oesophageal cancers diagnosed in England between 1971 and  2013 were extracted. Multiple imputation was used to predict morphology  data were missing. Incidence rates were modelled and extrapolated to  2037 using age-period-cohort models.


The OAC  age-standardised incidence rate (ASRs) increase was greatest from 1972  to 1992 (from 4.8 to 12.3 for men and 1.1 to 3 per 100,000 for women)  and slowed from 1992 to 2012 (with an increase to 17 for men and 3.8 per  100,000 for women). OSCCs rates decreased from 7.5 to 4.9 from 1972 to  2012 for men. For women, ASRs increased from 5.5 to 5.9 between 1972 and  1992 and then decreased to 4.7 per 100,000 until 2012. Rates until 2032  are predicted to stay stable for OACs and further decrease for OSCCs.


Imputing missing morphology allowed accurate and up-to-date estimates of trends and projections. We observed a slowing down of the increase in OAC ASRs and an overall decrease in OSCC ASRs.